No. 66 - Weight Management / Energy

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Weight Management
Weight Management
Calorie Burn
Calorie Burn
Lean Body Composition
Lean Body Composition
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Targets microbial activity involved in satiety, energy efficiency, and GLP-1 responsiveness. Designed to complement weight maintenance efforts from within.

Dial In Your Microbiome Strategy

How difficult is it for you to maintain a healthy weight and/or body composition? 3
Not Very Difficult Very Difficult
How long has this been difficult for you? 3
Months Years
Your Strategy
Targeted Optimization
Your Protocol
8–12 weeks, daily
Complete Protocol
3 bottles
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Brief Discussion MAIOME's No. 66

Listen to this short discussion on how No. 66 was designed to help support weight management and energy levels.
0:00 0:00

No. 66: Precision Feeding. Precision Limiting. Nothing Left to Chance.*

Designed to influence specific microbial pathways by promoting beneficial bacteria and inhibiting less favorable strains — helping create a gut environment that supports healthy weight management, lean body composition, and efficient calorie burn.

↑Metabolism-Supporting Bacteria*

Feeds microbes associated with healthy fat metabolism, efficient calorie utilization, and lean body composition

↓Metabolic Drag Bacteria*

Helps limit microbes associated with excess calorie retention and compromised metabolic efficiency

↓Weight Management Microbiome Stress*

Supports a healthier internal environment by reducing the microbial contributors to metabolic inefficiency and weight management challenges

↑Lean Metabolic Resilience*

Supports a more adaptable gut ecosystem oriented toward healthy weight management and sustained calorie-burning efficiency

The Science That Makes MAIOME No. 66 So Unfair

(In The Best Way)
1
Supports the Weight Management Microbiome — The Gut Ecosystem That Influences How Your Body Handles Calories*
The weight management microbiome describes the specific bacterial balance associated with healthy calorie utilization, fat metabolism, and lean body composition. No. 66 promotes Ruminococcus, Bacteroides, and Prevotella — populations associated with a more metabolically efficient gut environment and healthier body composition outcomes.*
2
Targets the Bacterial Populations Associated With Metabolic Inefficiency*
Firmicutes, Enterorhabdus, and Subdoligranulum are associated with gut conditions that contribute to excess calorie retention and compromised metabolic efficiency. No. 66 discourages these populations while nourishing the microbial balance that supports healthy calorie burn and more efficient energy expenditure.*
3
Supports the Gut-Adipose Axis — The Biological Connection Between Your Microbiome and Body Composition*
The gut-adipose axis is an emerging framework describing how microbial metabolites influence fat storage, energy regulation, and body composition — through short-chain fatty acid production, appetite-related signaling, and metabolic hormone support. No. 66 is formulated to support the bacterial populations that keep this axis oriented toward lean body composition.*
4
Builds a Gut Ecosystem Where Your Metabolism Works For You*
Resistant maltodextrin, grape seed extract, beta glucan, and chlorogenic acid — the precision prebiotic complex in No. 66 — work together to shift the gut toward the bacterial balance associated with healthy weight management and sustained calorie-burning efficiency. Your metabolism isn't broken. It may just need the right microbial environment to perform.*

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Your Microbiome Feels The Love

ON DAY ONE

Day 1

YOUR MICROBIOME BEGINS SHIFTING TOWARD A LEANER METABOLIC STATE. Resistant maltodextrin and grape seed extract immediately begin suppressing Firmicutes, Streptococcus, and Enterorhabdus — the bacterial populations associated with excess calorie extraction and metabolic inefficiency.

Day 30

A WEIGHT-SUPPORTIVE GUT ENVIRONMENT STARTS TO TAKE HOLD. Ruminococcus and Bacteroides populations grow, producing metabolites that improve fat metabolism and reduce the microbial pressure that drives calorie retention.

Day 90

YOUR GUT SUPPORTS HEALTHY CALORIE BURN AND LEAN BODY COMPOSITION. With Subdoligranulum and Howardella in decline, the chronic metabolic drag they create quiets — and the microbiome begins actively supporting energy expenditure rather than working against it.

Day 180

YOUR METABOLIC MICROBIOME IS ACTIVELY OPTIMIZING. Six months of targeted bacterial rebalancing has strengthened the populations — Prevotella, Bifidobacterium, Lactobacillus — that optimize appetite signaling and fat metabolism.

Day 365

RESILIENT METABOLIC BALANCE IS YOUR NEW FOUNDATION. The structural microbial drivers of weight resistance have been systematically addressed. Lean body composition and sustained calorie burn are the durable result.

8 Science-Backed Ingredients For Weight Management Optimization

Resistant Maltodextrin
Metabolic Efficiency Fermentation Selectivity

A slowly fermented prebiotic fiber that selectively nourishes Ruminococcus and Bacteroides — populations associated with healthy calorie utilization and lean body composition — while creating a less hospitable environment for Firmicutes and Enterorhabdus, the bacterial populations associated with excess calorie retention and compromised metabolic efficiency.

Grape Seed Extract 95%
Gut-Adipose Axis Modulation Metabolic Environment

Functions as a polyphenol-based microbiome modulator that works through the gut-adipose axis — the biological connection between gut microbial balance and how the body manages fat storage and energy expenditure. Discourages Subdoligranulum and Howardella while supporting the bacterial conditions associated with healthy fat metabolism and more efficient calorie burn.

Beta Glucan 70%
Appetite Signaling Metabolic Resilience Ecosystem Support

A viscous prebiotic fiber that supports the weight management microbiome by promoting Prevotella, Bifidobacterium, and Lactobacillus — populations associated with healthy appetite-related signaling and sustained metabolic efficiency. Works synergistically with resistant maltodextrin to create a comprehensive prebiotic foundation for the weight management microbiome.

Xylooligosaccharide
Colonization Selectivity Lean Body Support

Selectively nourishes the metabolic microbiome populations that healthy calorie burn and lean body composition depend on — while discouraging the less favorable strains associated with metabolic drag. Works synergistically with resistant maltodextrin and beta glucan to create a three-fiber prebiotic system that comprehensively supports the weight management microbiome.

Mulberry Leaf Extract 4:1
Metabolic Signaling Gut-Adipose Axis Energy Balance

Provides bioactive compounds — including deoxynojirimycin — that support healthy metabolic signaling along the gut-adipose axis, contributing to the stable internal metabolic environment that healthy weight management and sustained energy production depend on. Works synergistically with the prebiotic fiber system in No. 66 to support comprehensive metabolic microbiome balance.

Chlorogenic Acid
Modulation Metabolic Environment Selectivity

A polyphenol compound that functions as a precision microbiome modulator — discouraging the bacterial populations associated with metabolic inefficiency while supporting the gut conditions linked to healthy calorie utilization and lean body composition. Works synergistically with grape seed extract to create a comprehensive polyphenol modulation layer within No. 66's formula.

Turmeric Powder
Gut-Adipose Axis Modulation Metabolic Resilience

Functions as a precision microbiome modulator that supports the gut-adipose axis by discouraging less favorable populations while nourishing the bacterial conditions associated with healthy metabolic function. Curcumin's unique interaction with gut bacteria makes it a valuable contributor to the comprehensive weight management microbiome environment No. 66 is designed to create.

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