No. 59 - GI Daily Regularity

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Regularity
Regularity
Bowel Function
Bowel Function
Relief From Occasional Constipation
Relief From Occasional Constipation
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Supports microbial diversity and motility patterns tied to digestive regularity. Nourishes butyrate-producing species to help ease occasional sluggishness without reliance on stimulant laxatives.

Dial In Your Microbiome Strategy

How often do you experience constipation or irregularity? 3
Rarely Frequently
How long have you been experiencing this? 3
Months Years
Your Strategy
Targeted Optimization
Your Protocol
8–12 weeks, daily
Complete Protocol
3 bottles
Complete Protocol Now

Brief Discussion On MAIOME's No. 59

Listen to this short conversation around how No. 59 is designed to support daily regularity when it comes to digestive wellness.
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No. 59: Precision Feeding. Precision Limiting. Nothing Left to Chance.*

Designed to influence specific microbial pathways by promoting beneficial bacteria and inhibiting less favorable strains — helping create a more consistent, comfortable digestive environment.

↑Motility-Supporting Bacteria*

Feeds microbes associated with healthy bowel transit and consistent digestive rhythm

↓Gas-Generating Bacteria*

Helps limit microbes associated with occasional bloating and digestive discomfort

↓Bowel Irregularity*

Supports a more settled lower bowel environment by reducing the microbial pressure linked to inconsistent function

↑Digestive Regularity*

Supports a more predictable, comfortable daily digestive experience

The Science That Makes MAIOME No. 59 So Unfair

(In The Best Way)
1
Rebalances the Motility Microbiome So Your Bowel Works With You, Not Against You*
Most people don't realize that bowel transit speed is partly governed by bacteria. No. 59 promotes Actinobacteria and Collinsella — microbial populations that produce the metabolites your gut uses to maintain healthy, consistent movement through the lower bowel.*
2
Targets the Fermentation Imbalance Behind Bloating and Gas*
Desulfovibrio and Synergistes are bacteria that produce hydrogen sulfide and other fermentation byproducts associated with gas and bloating. No. 59 is precision-formulated to discourage these populations and support a more comfortable, settled digestive environment.*
3
Supports the Lower Bowel Ecosystem That Regularity Depends On*
Regularity isn't just about fiber — it's about having the right bacterial balance in the lower GI tract. By promoting Prevotella, Bifidobacterium, and Lactobacillus, No. 59 supports the microbial conditions that contribute to healthy stool formation, comfortable transit, and predictable daily function.*
4
Builds a Digestive Environment Designed to Last*
No. 59 isn't a laxative — it's a microbiome rebalancing protocol. Over time, by discouraging Clostridium and Betaproteobacteria while nourishing beneficial populations, it supports a gut ecosystem where regularity becomes the baseline, not the exception.*

Not sure where to start? Take our MyBiome Match™ quiz

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Your Microbiome Feels The Love

ON DAY ONE

Day 1

YOUR GUT MICROBIOME BEGINS SHIFTING TOWARD REGULARITY. Galactooligosaccharide and resveratrol immediately begin suppressing Clostridium and Desulfovibrio — the bacterial populations whose fermentation byproducts slow motility, generate gas, and drive the bloating and irregularity that disrupt daily comfort.

Day 30

A MORE FUNCTIONAL BOWEL ENVIRONMENT STARTS TO TAKE HOLD. Betaproteobacteria and Synergistes decline as Actinobacteria and Collinsella grow, producing metabolites that support healthy transit time and reduce the microbial pressure driving occasional constipation.

Day 90

YOUR GUT SUPPORTS CONSISTENT, COMFORTABLE DAILY REGULARITY. With Dehalobacterium in retreat, the fermentation imbalance it creates quiets — bloating and gas ease, and the lower bowel begins functioning with the consistency it was designed for.

Day 180

YOUR DIGESTIVE MICROBIOME IS ACTIVELY OPTIMIZING. Six months of targeted rebalancing has strengthened Prevotella, Bifidobacterium, and Lactobacillus — the populations that regulate stool formation, bowel motility, and the mucosal environment of the lower GI tract.

Day 365

RESILIENT DIGESTIVE BALANCE IS YOUR NEW FOUNDATION. The structural microbial drivers of irregularity and bloating have been systematically addressed. Daily regularity and comfortable bowel function are the durable result.

6 Science-Backed Ingredients To Modulate Your Microbiome

Galactooligosaccharide
Fermentation Motility Colonization

A highly selective prebiotic fiber that preferentially feeds Bifidobacterium and Lactobacillus — the bacterial populations most closely associated with healthy bowel transit and consistent digestive rhythm. As these populations grow, they produce short-chain fatty acids that fuel the cells lining the lower bowel, supporting the gut environment that comfortable daily regularity depends on.

Xylooligosaccharide
Selectivity Resilience Lower GI Support

Works at low levels to selectively nourish beneficial bacterial populations while creating a less hospitable environment for the gas-generating and motility-disrupting microbes associated with occasional constipation and bloating. Particularly effective at supporting Bifidobacterium colonization in the lower GI tract — where regularity is won or lost.

Quercetin
Modulation Adhesion Gut Environment

A polyphenol compound that functions as a precision microbiome modulator — discouraging less favorable populations from adhering and proliferating in the lower bowel while supporting the microbial conditions associated with comfortable, consistent digestive function. Works synergistically with the prebiotic fibers in No. 59 to enhance the selectivity of the overall formula.

Grape Seed Extract 95%
Barrier Support Selectivity Gut Environment

Functions as a polyphenol-based microbiome modulator that supports gut barrier integrity by promoting beneficial populations while discouraging the microbes associated with digestive discomfort and bowel irregularity. Its proanthocyanidin compounds reinforce the mucosal environment that healthy lower bowel function depends on.

Trans-Resveratrol (Polygonum Cuspidatum Extract 98%)
Modulation Selectivity Motility Support

Functions as a polyphenol-based microbiome modulator that selectively discourages Clostridium and Betaproteobacteria — bacterial populations associated with sluggish motility and digestive discomfort — while supporting the microbial conditions that contribute to a more settled, consistent lower bowel environment.

Resistant Maltodextrin
Fermentation Transit Support Stability

A slowly fermented prebiotic fiber that moves through the gut gradually, feeding beneficial populations along the entire lower GI tract rather than fermenting rapidly in the upper gut. This gradual fermentation profile supports a more settled bowel environment — contributing to the consistent digestive rhythm that daily regularity depends on.

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