No. 58 - GI Calming Bowel Support

Regular price $52.00
Sale price $52.00 Regular price
Unit price
$0.87item
Bowel Function
Bowel Function
Comfort
Comfort
Regularity
Regularity
Download Information Sheet

Designed for those who need to modulate and promote healthy gut bacteria, this targeted formula helps re-balance  digestive activity and soothe digestive tension, day after day.

Dial In Your Microbiome Strategy

How often do you experience digestive discomfort, irritation or irregularity? 3
Rarely Frequently
How long have you experienced this? 3
Months Years
Your Strategy
Targeted Optimization
Your Protocol
8–12 weeks, daily
Complete Protocol
3 bottles
Complete Protocol Now

Brief Discussion on MAIOME's No. 58

Listen to this short conversation around how No. 58 is designed to help support digestive and lower bowel comfort and regularity.
0:00 0:00

No. 58: Precision Feeding. Precision Limiting. Nothing Left to Chance.*

Designed to influence specific microbial pathways by promoting beneficial bacteria and inhibiting less favorable strains — helping create a calmer, more comfortable bowel environment.

↑Comfort-Supporting Bacteria*

Feeds microbes associated with a settled, comfortable lower bowel environment

↓Discomfort-Associated Bacteria*

Helps limit specific microbes associated with digestive unease and bowel irregularity

↓Digestive Stress*

Supports a balanced environment to minimize irritation and stress brought on by external factors.

↑Bowel Calm*

Supports a more stable, comfortable digestive experience day to day

The Science That Makes MAIOME No. 58 So Unfair

(In The Best Way)
1
Addresses the Microbial Root of Digestive Discomfort*
Digestive discomfort rarely has a single cause — but microbial imbalance in the lower bowel is a consistent contributor. No. 58 is formulated to discourage Synergistes, Desulfovibrio, and Ruminococcaceae — populations associated with the fermentation patterns that drive cramping, irregularity, and bowel unease.*
2
Nourishes the Gut Lining That Comfortable Digestion Depends On*
Eubacterium and Bacteroides — two of the populations No. 58 is designed to promote — produce short-chain fatty acids that serve as the primary fuel source for colonocytes, the cells that line your lower bowel. A well-nourished gut lining is the foundation of comfortable, consistent digestive function.*
3
Supports the Calming Microbiome — A Gut Ecosystem Built for Ease*
Emerging research points to what could be called a "calming microbiome" — a bacterial balance in the lower GI that produces fewer discomfort-associated fermentation byproducts and more of the metabolites that support bowel ease. No. 58 is precision-formulated to help shift your gut toward that balance.*
4
Promotes Bowel Resilience So Comfort Becomes Your New Normal*
By discouraging Betaproteobacteria and Dehalobacterium while strengthening Bifidobacterium, Lactobacillus, and Enterococcus, No. 58 supports a lower bowel environment that is more stable, more resilient, and less reactive to the daily variables that typically disrupt digestive comfort.*

Not sure where to start? Take our MyBiome Match™ quiz

TAKE THE ASSESSMENT →

Your Microbiome Feels The Love

ON DAY ONE

Day 1

YOUR GUT MICROBIOME BEGINS SHIFTING TOWARD DIGESTIVE CALM. Galactooligosaccharide and chlorogenic acid immediately begin suppressing Synergistes, Desulfovibrio, and Ruminococcaceae — the bacterial populations whose fermentation activity drives the discomfort, cramping, and unpredictability that disrupt daily life.

Day 30

A CALMER, MORE COMFORTABLE BOWEL ENVIRONMENT STARTS TO TAKE HOLD. Betaproteobacteria and Dehalobacterium decline as Eubacterium and Enterococcus grow, producing short-chain fatty acids that soothe the gut lining and begin reducing the chronic irritation driving bowel dysfunction.

Day 90

YOUR GUT SUPPORTS COMFORTABLE, CONSISTENT LOWER BOWEL FUNCTION. With the primary gas- and discomfort-generating populations in retreat, bloating eases and the bowel begins operating with the regularity and calm it was designed for.

Day 180

YOUR DIGESTIVE MICROBIOME IS ACTIVELY OPTIMIZING. Six months of targeted rebalancing has strengthened Bifidobacterium, Lactobacillus, and Bacteroides — the populations that maintain mucosal integrity, regulate motility, and keep the lower bowel environment stable and resilient.

Day 365

RESILIENT DIGESTIVE CALM IS YOUR NEW FOUNDATION. The structural microbial drivers of bowel discomfort and irregularity have been systematically addressed. Comfortable bowel function and lasting inner calm are the durable result.

5 Science-Backed Ingredients To Comfort Your Digestive System

Galactooligosaccharide
Nourishment Barrier Support Calm

Selectively feeds Bifidobacterium, Lactobacillus, and Bacteroides — populations that produce the butyrate and acetate that serve as the primary fuel for colonocytes, the cells lining your lower bowel. A well-nourished bowel lining is the structural foundation of comfortable, calm digestive function.

Resistant Maltodextrin
Fermentation Motility Stability

Functions as a slowly fermented prebiotic fiber that moves through the gut gradually — feeding beneficial populations along the entire lower GI tract and supporting a more settled bowel environment. This gradual fermentation profile reduces the microbial conditions associated with gas, bloating, and digestive unease.

Grape Seed Extract 95%
Barrier Integrity Selectivity Gut Environment

Supports gut barrier integrity by promoting the beneficial populations associated with a calm, comfortable lower bowel while discouraging the microbes whose fermentation byproducts drive digestive discomfort. Its proanthocyanidin compounds reinforce the mucosal lining that comfortable bowel function depends on.

Xylooligosaccharide
Colonization Selectivity Lower GI Support

Works synergistically with galactooligosaccharide to create a comprehensive prebiotic environment across the entire lower GI tract — selectively nourishing Eubacterium and Bifidobacterium while creating a less hospitable environment for the populations associated with bowel discomfort and irregularity.

Chlorogenic Acid
Modulation Selectivity Antioxidant

A polyphenol compound that functions as a precision microbiome modulator — discouraging Synergistes, Desulfovibrio, and Ruminococcaceae while supporting the beneficial populations that contribute to a calmer, more comfortable lower bowel environment. Works synergistically with the prebiotic fibers in No. 58 to enhance microbial selectivity throughout the GI tract.

Frequently Asked Questions

What are Maiome supplements designed for?

How does this supplement work?

What are the main benefits of this product?

Who should consider taking this supplement?

Are Maiome products suitable for daily use?

What is “inflammaging”?

Why is gut barrier health important?

Are there any side effects?