No. 47 - Sleep / Gut-Brain Axis / Neurotransmitter

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Sleep Quality
Sleep Quality
Neurotransmitter
Neurotransmitter
Gut/Brain Axis
Gut/Brain Axis

A unique prebiotic complex formulated to support the microbiome’s influence on neurotransmitter signaling and restful sleep. Targets key species linked to serotonin and GABA production.

Dial In Your Microbiome Strategy

How often do you experience difficulty falling or staying asleep and/or unwanted changes in mood? 3
Rarely Frequently
How long have you been experiencing this? 3
Months Years
Your Strategy
Targeted Optimization
Your Protocol
8–12 weeks, daily
Complete Protocol
3 bottles
Complete Protocol Now

Brief Discussion on MAIOME's No. 47

Listen to this short discussion that outlines how No. 47 is designed to support sleep, mood, the gut-brain axis and neurotransmitter production.
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No. 47: Precision Feeding. Precision Limiting. Nothing Left to Chance.*

Designed to influence specific microbial pathways by promoting beneficial bacteria and inhibiting less favorable strains — helping create a gut environment more conducive to restful sleep and healthy neurotransmitter production.

↑Gut-Brain Axis Bacteria*

Feeds microbes associated with healthy serotonin precursor availability and gut-brain communication

↓Sleep-Disrupting Bacteria*

Helps limit bacterial imbalance associated with compromised neurotransmitter production and disrupted sleep patterns

↓Neurological Microbiome Stress*

Supports a healthier gut-brain environment by reducing the microbial contributors to restless, non-restorative sleep

↑Sleep Quality

Supports a more adaptable gut-brain axis and a more consistent, restorative nightly sleep experience

The Science That Makes MAIOME No. 47 So Unfair

(In The Best Way)
1
Supports the Gut-Brain Axis — The Biological Highway Between Your Microbiome and Your Mind*
The gut-brain axis is the bidirectional communication network connecting your gut microbiome to your central nervous system via the vagus nerve, immune signaling, and microbial metabolite production. No. 47 is formulated to support the bacterial populations — Faecalibacterium, Bifidobacterium, and Akkermansia — that contribute to healthy signaling along this pathway.*
2
Addresses the Microbial Populations That Disrupt Healthy Neurotransmitter Production*
Approximately 90% of the body's serotonin is produced in the gut, and the bacteria present there play a significant role in supporting that process. No. 47 discourages Enterorhabdus, Howardella, and Slackia — populations associated with compromised neurotransmitter precursor availability — while nourishing those that support healthy production.*
3
Supports the Sleep Microbiome — The Bacterial Balance That Restful Nights Depend On*
The sleep microbiome is an emerging concept describing the specific bacterial balance that supports healthy sleep-wake signaling through the gut-brain axis. By promoting Blautia and Bacteroides alongside Faecalibacterium, No. 47 supports the microbial conditions associated with more consistent, restorative sleep patterns.*
4
Builds a Gut Environment Where Calm Becomes Structural*
Poor sleep isn't just a brain problem — it often has microbial roots. By discouraging Firmicutes and Streptococcus while strengthening the gut-brain axis populations, No. 47 supports a gut ecosystem where healthy neurotransmitter production and consistent sleep quality become durable outcomes rather than nightly variables.*

Not sure where to start? Take our MyBiome Match™ quiz

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Your Microbiome Feels The Love

ON DAY ONE

Day 1

YOUR GUT MICROBIOME BEGINS SHIFTING TOWARD DEEPER, MORE RESTORATIVE SLEEP. Xylooligosaccharide and turmeric immediately begin discouraging Enterorhabdus, Howardella, and Firmicutes — bacterial populations associated with disrupted gut-brain signaling — while beginning to nourish the microbial environment that supports healthy neurotransmitter production.

Day 30

A SLEEP-SUPPORTIVE GUT ENVIRONMENT STARTS TO TAKE HOLD. As Subdoligranulum and Slackia decline, Faecalibacterium and Akkermansia grow — supporting the gut-brain axis conditions that contribute to healthy serotonin precursor availability and more consistent sleep patterns.

Day 90

YOUR GUT SUPPORTS HEALTHY NEUROTRANSMITTER PRODUCTION AND SLEEP QUALITY. With the primary disruptors of gut-brain communication receding, the microbial conditions that support serotonin pathway function become more established — and restful, consistent sleep becomes more accessible.

Day 180

YOUR GUT-BRAIN AXIS IS ACTIVELY OPTIMIZING. Six months of targeted rebalancing has strengthened Bifidobacterium, Blautia, and Bacteroides — populations that produce neuroactive metabolites and support the bidirectional communication between gut and brain that underlies healthy sleep.

Day 365

RESILIENT SLEEP AND A HEALTHY GUT-BRAIN AXIS ARE YOUR NEW FOUNDATION. The microbial imbalances that contributed to disrupted sleep and impaired neurotransmitter production have been systematically addressed. Deep, consistent rest and lasting neurological balance are the durable result.

7 Science-Backed Ingredients To Balance The Gut-Brain Axis

Xylooligosaccharide
Gut-Brain Support Colonization Selectivity

Selectively nourishes Faecalibacterium and Bifidobacterium — two of the bacterial populations most closely associated with healthy gut-brain axis function and neurotransmitter precursor availability. By supporting these populations at the microbial level, xylooligosaccharide helps create the gut conditions that healthy sleep signaling depends on.

Resistant Maltodextrin
Fermentation Gut Environment Stability

A slowly fermented prebiotic fiber that supports a stable, consistent gut environment throughout the lower GI tract — reducing the fermentation variability that can disrupt the gut-brain signaling environment. Nourishes the broad bacterial ecosystem that healthy neurotransmitter production and sleep quality depend on.

Grape Seed Extract 95%
Barrier Integrity Gut-Brain Axis Selectivity

Supports the gut barrier integrity that healthy gut-brain axis communication depends on — promoting the beneficial populations associated with a resilient mucosal environment while discouraging the microbes whose byproducts can compromise the signaling pathway between gut and brain.

Chlorogenic Acid
Modulation Neurotransmitter Environment Selectivity

Discourages Enterorhabdus, Howardella, and Slackia — populations associated with compromised neurotransmitter production pathways — while supporting the gut environment that healthy serotonin precursor availability requires. The gut produces the majority of the body's serotonin, and the bacteria present there play a significant supporting role in that process.

Mulberry Leaf Extract 4:1
Signaling Gut-Brain Support Metabolic Balance

Provides bioactive compounds that support healthy metabolic signaling along the gut-brain axis — contributing to the stable internal environment that consistent, restorative sleep patterns depend on. Works synergistically with the prebiotic fibers in No. 47 to support the broader gut ecosystem that gut-brain communication requires.

Beta Glucan 70%
Barrier Support Signaling Resilience

Supports the gut barrier integrity that healthy gut-brain axis communication depends on. By nourishing Akkermansia and Blautia while reinforcing the mucosal environment, beta glucan helps maintain the structural conditions through which microbial metabolites travel to influence healthy neurotransmitter production and sleep quality.

Turmeric Powder
Modulation Antioxidant Selectivity

Functions as a precision microbiome modulator that discourages the less favorable populations competing with the gut-brain axis bacteria No. 47 is designed to support. Works synergistically with xylooligosaccharide and chlorogenic acid to create a comprehensive gut environment oriented toward healthy neurotransmitter production and more restorative sleep.

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