No. 23 - Longevity / Akkermansia Complex

One of the most selectively studied prebiotics for Akkermansia muciniphila support, xylooligosaccharide nourishes the mucosal environment that Akkermansia depends on to colonize and persist. Creates the foundational gut conditions that healthy Akkermansia levels require — while discouraging the competing strains that suppress its growth.

Functions as a long-chain prebiotic fiber that feeds beneficial populations throughout the entire GI tract — supporting Akkermansia's supporting cast of Eubacterium, Alistipes, and Enterococcus alongside Akkermansia itself. This ecosystem approach ensures the broader bacterial environment needed to sustain healthy Akkermansia levels is comprehensively nourished.

Pomegranate's ellagitannins are biotransformed by gut bacteria — including Akkermansia — into urolithins that support mucosal integrity and the broader longevity microbiome. By promoting the bacterial populations best equipped to perform this biotransformation, No. 23 unlocks pomegranate's full Akkermansia-supportive potential.

Research has identified resveratrol as one of the few compounds that directly supports Akkermansia muciniphila growth. Discourages the competing populations — Enterorhabdus, Howardella, and Firmicutes — that suppress Akkermansia levels, while supporting the mucosal integrity and metabolic signaling environment that healthy Akkermansia colonization depends on.

A soluble prebiotic fiber that supports the diverse gut ecosystem Akkermansia needs to thrive — nourishing the broader bacterial community while contributing to the stable mucosal environment that Akkermansia muciniphila colonization depends on. Works synergistically with inulin and xylooligosaccharide to create a comprehensive Akkermansia support system.

Vitamin D is one of the few nutrients with a direct and well-documented relationship with both gut barrier integrity and microbial diversity — two of the foundational conditions that healthy Akkermansia muciniphila colonization depends on. Vitamin D receptors are expressed throughout the gut lining, where they play a significant role in supporting the mucosal environment that Akkermansia inhabits and depends on for survival. Research has also identified a bidirectional relationship between Vitamin D status and Akkermansia levels — healthy Vitamin D supports the conditions where Akkermansia thrives, and a thriving Akkermansia population supports the gut barrier integrity that healthy Vitamin D absorption requires. In No. 23, cholecalciferol works in concert with the precision prebiotic complex — not just as a general wellness nutrient, but as a specific and targeted contributor to the Akkermansia longevity ecosystem the formula is designed to build.